As a Director of Proteomic Target Discovery, you will focus on building and leading a team to developing and deploying state-of-the-art proteomic methods at scale to explore novel biology and uncover new target and disease axes with a focus on the cell surface as a key driver of the company's internal target ID engine. The ideal candidate is expected to thrive in a multidisciplinary environment, smoothly collaborate with other Arena BioWorks research teams to explore novel biology, support internal discovery projects, and skillfully manage a team.
Specific Responsibilities:
Independently build and a lead a team to develop and apply quantitative proteomic methods in relevant cell lines, disease models and tissue samples.
Profile cell surface biology at unprecedented resolution by creatively deploying novel proximity labeling methods, N-terminomics and other bio-orthogonal labeling approaches.
Develop and optimize robust proteomic workflows to reliably prioritize disease-associated molecular targets, higher-order protein complexes and pathways from integrative -omics analyses.
As a senior leader in the organization reporting to the Pro Chair, you will collaboratively devise the overall strategy for the Protein Therapeutics group as well as intergroup collaborations with additional Pro's at Arena.
Working collaboratively within the Protein Therapeutics group as a leader/mentor and team member, you will join selection scientists, protein scientists, and biologists, to identify and validate novel therapeutic targets that will trigger new discovery campaigns.
Generate data in a timely manner; lead discovery initiatives; organize and present at project meetings.
Oversight of PhD-level scientists and senior scientists, laboratory technicians, research assistants, and fellows participating in projects, including assistance in training, experimental design, and implementation.
Assume additional responsibilities as needed across the Protein Therapeutics Group.
Qualifications:
Ph.D. in Biochemistry, Bioengineering, Biophysics, Molecular Biology, or related field, with 10+ years postgraduate experience in an academic or industry setting.
Demonstrated expertise leading the experimental design and execution of mass spectrometry-based approaches for protein identification and quantification in a drug discovery setting. Deep expertise in cell surface biology, proximity labelling methods, N-terminomics, etc. is a highly desirable.
Highly experienced with state-of-the-art quantitative proteomics workflows from data acquisition to analysis to interpretation. Familiarity with both DDA and DIA methods is a big plus, as is SILAC/TMT-based stable isotope labeling methods for sample multiplexing.
Experience operating, maintaining, and troubleshooting nano LC instrumentation and current models of ThermoFisher and Bruker mass spectrometers.
Collaboration-first mindset, with a desire to routinely communicate and engage with diverse areas of expertise to uncover novel disease biology.
Highly adaptable, strong problem solver, with the ability to identify problems and find innovative solutions.
Compassionate leader, mentor and team-player in dynamic research ecosystem with minimal hierarchy with strong verbal and written communications skills.
Highly organized and proficient in documentation, LIMS, and presentation of data.
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