Position Summary:
This is an exciting opportunity to join our growing Neuroscience team. As client's portfolio of preclinical and clinical programs continues to expand, the candidate for this postion will have a tremendous opportunity to help us drive our translational strategy for current and upcoming clinical stage neuroscience PROTAC drug candidates. We are seeking a highly motivated and collaborative candidate who is passionate about advancing novel neurodegeneration therapies for a laboratory-based position. This individual will have strong experimental skills and will utilize a variety of techniques to profile pharmacokinetic-phamacodynamic properties and downstream functional mechanisms of PROTAC drug candidates.
This position reports to a Senior Director, Neuroscience and will be located at our headquarters in New Haven, CT. Principal Responsibilities:
As part of the Neuroscience team, the candidate will assist in the assessment of target engagement, pathway engagement and evaluation of pharmacokinetic and pharmacodynamic (PK/PD) relationships as part of ongoing preclinical research studies across multiple programs. Key responsibilities of this role include, but are not limited to: Independently design and execute experiments, and perform data analysis Leverage multiple assay platforms to assess mechanisms/pathways associated with PROTAC degrader molecules Interact and collaborate with neuroscience, chemistry, translational and clinical team members to contribute to drug discovery and development program progression Document, compile and interpret experimental data; manage electronic laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner Keep up-to-date on relevant scientific literature Qualifications: Cell culture (cell lines, iPSC-derived neurons, primary neurons); including cell line maintenance, transfection, and compound treatment Ex vivo and/or clinical sample handling and processing for protein extraction and detection Proficient in molecular and cellular biology techniques and biochemical assays, including but not limited to immunoblotting, ELISA, and MSD Biomarker expierence is a plus Plate-based assay development and validation experience is desirable Innovative and creative individual with the ability to work independently and in a team environment, prioritize experimental design and data analysis, and take ownership of multiple projects Well organized and demonstrated ability to prepare technical reports, summaries, protocols,etc. Highly motivated with strong interpersonal and communication skills Education: MS in biological sciences with a minimum of 5 years of related experience; previous industry experience is a plus. Neuroscience background or understanding is preferred but not required
