Scientist I : D3B Center

Scientist I : D3B Center


Scientist I : D3B Center

Details of the offer

LOC_COLKET:Colket Translational ResearchReq ID:51281 Shift: Days Employment Status:Regular : Full Time

Job Summary 13;

The Center for Data Driven Discovery in Biomedicine (D and sup3;b) is a transformative healthcare discovery ecosystem at Childrens Hospital of Philadelphia (CHOP) Research Institute, one of the largest pediatric research institutes in the U.S.
D3bs multi:disciplinary team brings together experts in basic science, precision medicine, bioinformatics and genomic research to provide innovative and personalized care for children through collaborative, data:driven science. Under its open:science model, the center drives the secure generation and integration of complex genomic and clinical patient data, and develops the open:access platforms that support collaborative discovery. Researchers worldwide are able to access this information and work together to fully empower and share novel approaches to biological targets for precise, less toxic clinical treatments on behalf of children.
D3b center is looking for a Research Scientist to support its translational research and data driven laboratory projects. The candidate will be responsible for the development of patient tumor derived research models (cell lines, patient derived xenografts, organoids) and pursuing biomarker discovery research in the preclinical research unit. The person will work in Dr. Resnicks laboratory under the mentorship of the laboratory director Dr. Mateusz Koptyra. We are looking for a dedicated person who will support all aspects of the pediatric brain tumor biomarker explorations efforts; from sample processing and model generation through data generation and analysis to the basic research validation studies. The selected candidate will work closely with the principal investigator and support project strategy providing scientific expertise from the ground up and guiding the function of the research unit.

Job Summary (Continued) 13;

Essential job functions and duties
: Assists the laboratory director in conducting research of significant value in basic and/or translational science projects
: Supports hands:on and helps to manage the effort for the generation of specimen derived research models
: Develops scientific questions around the centers projects and executes the hypothesis by conducting the wet bench research work
: Reviews raw and computed data from DNA/RNA/proteomic profiling; designs and executes the validation studies
: Collaborates with bioinformatics team, fellow researchers, and external institutions to develop cooperative research initiatives
: Performs and documents experiments in a rigorous and reproducible manner
: Collects, analyzes and presents data at both internal and external meetings
: Trains and/or manages the technical staff and students in lab procedures and project pipelines
: Generates and reviews manuscripts for peer:reviewed journals
: Assists in composing/developing applications for grants/contracts for funding of research projects
: Promotes free discussion, research progress, and overall morale

Minimum requirements
: PhD in life sciences (oncology, immunology, pathology, molecular biology, cell biology or a related field), 1:3 years post:doctoral experience or scientifically relevant experience preferred
: Proficiency in cell culture, basic cell analysis methods and animal work is required
: Previous experience with development of specimen derived research models is a plus
: Experience with high throughput data generation techniques (WGS, RNAseq, methylation profiling) is a plus
: Previous experience with development of specimen derived research models is preferred
: Experience in the analysis of large datasets is preferred
: Previous experience with biomarker discovery and validation process is a plus
: Demonstrable experience with record keeping and quality measures is required
: Technical proficiency, ability to learn new techniques quickl

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