Bioinformatics Associate I

Bioinformatics Associate I
Company:

Infobahn Softworld Inc.


Place:

California


Area:

Programmer

Bioinformatics Associate I

Details of the offer

Role type:
Bioinformatics Analyst/Statistical programmer for the analysis of high-throughput NGS data for CRISPR screening

Duties

Processing, quality control and statistical analysis of high-throughput functional genomics screening data (CRISPR screens, barcoding experiments, RNAi screens)

Processing and quality control of our internal CRISPR functional screening projects using internally-developed R packages.

Statistical analysis in the R language of CRISPR screens using standard analytic tools (e.g. differential analysis using voom/limma).

Import, processing and analysis of external CRISPR screens datasets.

Integration of CRISPR screening data into different internal visualization tools.

Education

Master's degree or PhD in Computational Biology, Bioinformatics, Biostatistics, or similar experience working in a quantitative biosciences position.

Core skills

Strong statistical software engineering skills and Unix/Linux proficiency

High level of proficiency with R programming language

Good understanding of linear modelling and standard different analysis tools (limma/voom, edgeR, etc.)

Experience with R shiny preferable.

Experience with at least one the following high-throughput genomics platforms: RNA-seq, ChIP-seq, ATAC-seq, DNase, SNP arrays, methylation arrays, Whole-genome bisulfite sequencing (WGBS), CRISPR/Cas9 functional screens.

Familiarity with genetics and genomics data, with deeper understanding for at least one area of genomics.

Preferred skills

Understanding of the CRISPR/Cas9 system and experience with the design and processing of functional genomics screens

Advanced understanding of common statistical modeling approaches such as negative binomial modeling, logistic regression, lasso regression, mean/variance modeling, etc.

Experience with developing and publishing R packages

Requirements

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